Table of Contents

1. Alimta
2. Disease State
3. US Incidence and Mortality
4. Epidemiology
5. Clinical Presentation of MPM
8. Differential Diagnosis
9. Pathology
11. Prognostic Factors
12. IMIG Staging System
17. Current Treatment Modalities
18. Surgical Approaches
19. Radiotherapeutic Approaches
20. Multimodality Approaches
21. ALIMTA Chemical Structure
22. ALIMTA Mechanism of Action
23. Cell Membrane Transport of Antifolates
24. Pivotal Phase III Trial
29. Phase III Trial - Vitamin Supplementation
31. Phase III Trial - Baseline Characteristics
33. Phase III Trial - Median Survival
35. Phase III Trial - Median Number of Cycles
36. Phase III Trial - Adverse Events
39. Phase III Trial - Conclusions
40. Safety Considerations
42. Dosing and Scheduling
43. Dosage Reduction Guidelines
44. Dosage Reduction cont.
45. Dosage Reduction cont.
46. Summary
47. References
48. References cont.